Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Dec 16;15(24):3335-3336.
doi: 10.1080/15384101.2016.1235859. Epub 2016 Sep 29.

Hormesis running hot and cold

Arturo Bujarrabal  1   2 , Björn Schumacher  1   2
Affiliations
Comment

Hormesis running hot and cold

Arturo Bujarrabal et al. Cell Cycle. .
No abstract available

Keywords: DNA damage; adaptation; hormesis; stress response; yeast.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Conceptual possibilities of distinct consequences of adaptive and hormetic responses to toxic insults on fitness as measured by proliferation of yeast cells. Mild stress (yellow) such as low genotoxic treatments might trigger adaptive responses that under some circumstances could protect from severe stress (red). Markiewicz-Potoczny & Lydall observed adaptive but no hormetic responses in yeast cells with compromised telomere function or cell cycle regulation.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Schulz H. Ueber Hefegifte. Pflugers Arch Gesamte Physiol 1888; 42:517-41; http://dx.doi.org/10.1007/BF01669373 - DOI
    1. Calabrese EJ, Blain R. The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: An overview. Toxicol Appl Pharm 2005; 202:289-301; http://dx.doi.org/10.1016/j.taap.2004.06.023 - DOI - PubMed
    1. Vaiserman AM. Radiation hormesis: Historical perspective and implications for low-dose cancer risk assessment. Dose Response 2010; 8:172-191; PMID:20585444; http://dx.doi.org/10.2203/dose-response.09-037 - DOI - PMC - PubMed
    1. Garinis GA, et al.. Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat Cell Bio 2009; 11:604-15; http://dx.doi.org/10.1038/ncb1866 - DOI - PMC - PubMed
    1. Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B . DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature 2013; 501:416-20; PMID:23975097; http://dx.doi.org/10.1038/nature12452 - DOI - PMC - PubMed

LinkOut - more resources