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. 2017 Apr;30(2):121-125.
doi: 10.1007/s10334-016-0590-z. Epub 2016 Sep 29.

Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI

Jason Langley  1   2 , Daniel E Huddleston  3 , Christine J Liu  4 , Xiaoping Hu  5   6
Affiliations

Reproducibility of locus coeruleus and substantia nigra imaging with neuromelanin sensitive MRI

Jason Langley et al. MAGMA. 2017 Apr.

Abstract

Objectives: The purpose of this study was to assess the reproducibility of substantia nigra pars compacta (SNpc) and locus coeruleus (LC) delineation and measurement with neuromelanin-sensitive MRI.

Materials and methods: Eleven subjects underwent two neuromelanin-sensitive MRI scans. SNpc and LC volumes were extracted for each scan. Reproducibility of volume and magnetization transfer contrast measurements in SNpc and LC was assessed using intraclass correlation coefficients (ICC) and dice similarity coefficients (DSC).

Results: SNpc and LC volume measurements showed excellent reproducibility (SNpc-ICC: 0.94, p < 0.001; LC-ICC: 0.96, p < 0.001). SNpc and LC were accurately delineated between scans (SNpc-DSC: 0.80 ± 0.03; LC-DSC: 0.63 ± 0.07).

Conclusion: Neuromelanin-sensitive MRI can consistently delineate SNpc and LC.

Keywords: Locus coeruleus; Magnetic resonance imaging; Neuromelanin; Reproducibility; Substantia nigra.

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