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. 2017 Feb;151(2):425-430.
doi: 10.1016/j.chest.2016.09.009. Epub 2016 Sep 28.

Association of Sarcoidosis With Increased Risk of VTE: A Population-Based Study, 1976 to 2013

Patompong Ungprasert  1 , Cynthia S Crowson  2 , Eric L Matteson  3
Affiliations

Association of Sarcoidosis With Increased Risk of VTE: A Population-Based Study, 1976 to 2013

Patompong Ungprasert et al. Chest. 2017 Feb.

Abstract

Objective: The goal of this study was to investigate the risk of VTE among patients with sarcoidosis.

Methods: A cohort of 345 incident cases of sarcoidosis and 345 sex- and age-matched comparator subjects in Olmsted County, Minnesota, from 1976 to 2013 were identified from the comprehensive medical record linkage system. Medical records were reviewed for DVT and pulmonary embolism (PE). The cumulative incidence was estimated, adjusted for the competing risk of death. Cox proportional hazards models were used to compare the rate of development of these events between patients with sarcoidosis and the nonsarcoidosis comparison cohort.

Results: The prevalence of VTE, DVT, and PE prior to the index date was not significantly different between case and comparator subjects. The risk of incident VTE adjusted for age, sex, and calendar year was significantly higher among patients with sarcoidosis (hazard ratio [HR], 3.04 [95% CI, 1.47-6.29]). Significantly elevated risk was observed in both subtypes of VTE, with an HR of 3.14 (95% CI, 1.32-7.48) for DVT and an HR of 4.29 (95% CI, 1.21-15.23) for PE. A sensitivity analysis including only VTE events that occurred at least 6 months after the index date adjusted for age, sex, and calendar year revealed somewhat lower HRs: VTE, 2.73 (95% CI, 1.30-5.72); DVT, 3.00 (95% CI, 1.25-7.20); and PE, 3.58 (95% CI, 0.98-13.03).

Conclusions: An increased risk of VTE among patients with sarcoidosis was observed in this population-based cohort.

Keywords: DVT; VTE; epidemiology; pulmonary embolism; sarcoidosis.

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Figures

Figure 1
Figure 1
Cumulative incidence of VTE among patients with sarcoidosis (solid line) and comparators without sarcoidosis (dashed line).
See this image and copyright information in PMC

Comment in

  • Sarcoidosis and Risk of VTE: Validation With Big Data.
    Yaqoob ZJ, Al-Kindi SG, Zein JG. Yaqoob ZJ, et al. Chest. 2017 Jun;151(6):1398-1399. doi: 10.1016/j.chest.2017.03.022. Chest. 2017. PMID: 28599933 No abstract available.
  • Response.
    Ungprasert P, Crowson CS, Matteson EL. Ungprasert P, et al. Chest. 2017 Jun;151(6):1399. doi: 10.1016/j.chest.2017.03.021. Chest. 2017. PMID: 28599935 No abstract available.

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