Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Dec;16(12):789-802.
doi: 10.1038/nrc.2016.92. Epub 2016 Sep 30.

Epstein-Barr virus: more than 50 years old and still providing surprises

Lawrence S Young  1 , Lee Fah Yap  2 , Paul G Murray  3
Affiliations
Review

Epstein-Barr virus: more than 50 years old and still providing surprises

Lawrence S Young et al. Nat Rev Cancer. 2016 Dec.

Abstract

It is more than 50 years since the Epstein-Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV has revealed fundamental mechanisms of more general relevance to the oncogenic process. This Timeline article highlights key milestones in the 50-year history of EBV and discusses how this virus provides a paradigm for exploiting insights at the molecular level in the diagnosis, treatment and prevention of cancer.

PubMed Disclaimer

References

    1. Clin Cancer Res. 2007 Sep 1;13(17):5124-32 - PubMed
    1. Lancet Oncol. 2012 Jun;13(6):607-15 - PubMed
    1. J Virol. 1998 May;72(5):4371-8 - PubMed
    1. J Virol. 1994 Sep;68(9):6069-73 - PubMed
    1. N Engl J Med. 2004 Mar 25;350(13):1328-37 - PubMed

MeSH terms