Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 May;75(5):2424-8.
doi: 10.1073/pnas.75.5.2424.

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement

M C Carroll, J D Capra

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement

M C Carroll et al. Proc Natl Acad Sci U S A. 1978 May.

Abstract

This report describes a simple and reproducible assay for the fourth component of murine complement (C4). Utilizing this assay, experiments are described which conclusively demonstrate that the murine Ss protein (serum substance) is functional C4 and that ascitic fluid may be used as a source for isolating Ss. The evidence that Ss is functional C4 is: (i) pretreatment of mouse plasma with F(ab')2 anti-Ss completely abrogated the C4 hemolytic titer; and (ii) in the isolation of the Ss protein from ascitic fluid, Ss immunochemical activity and C4 functional activity coeluted in each step of a four-step purification procedure.

PubMed Disclaimer

References

    1. Genetics. 1963 Jan;48(1):9-25 - PubMed
    1. Biochem J. 1926;20(5):1028-35 - PubMed
    1. Prog Allergy. 1958;5:1-78 - PubMed
    1. Biochemistry. 1977 May 3;16(9):2008-15 - PubMed
    1. J Exp Med. 1977 Jul 1;146(1):257-70 - PubMed

Publication types

MeSH terms

LinkOut - more resources