Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Oct;62(4):325-7.
doi: 10.1016/S0377-1237(06)80097-3. Epub 2011 Jul 21.

Resistance to Antituberculosis Drugs in Pulmonary Tuberculosis

K Chand  1 , R Khandelwal  2 , V Vardhan  3
Affiliations

Resistance to Antituberculosis Drugs in Pulmonary Tuberculosis

K Chand et al. Med J Armed Forces India. 2006 Oct.

Abstract

Background: Incidence of drug resistance and pattern of susceptibility to antitubercular drugs in pulmonary tuberculosis amongst soldiers and their families was studied for four years at a military hospital in northwest India.

Methods: Identification and susceptibility tests were carried out as per procedures laid out in laboratory manual of Tuberculosis Research Centre (TRC), Chennai.

Results: Of the 172 strains of Mycobacterium tuberculosis (MTB) isolated from sputum samples, 150 (87.21%) were sensitive and 22 (12.79%) showed resistance to one or more antitubercular drugs. Acquired drug resistance was observed in 7 (31.82%) and primary drug resistance in 15 (68.18%) cases. Among 22 drug resistant cases, who were on short course chemotherapy (SCC), resistance to single drug was observed in 12 (54.54%), two drugs in 7 (31.82%) and to three or more drugs in 3 (13.64%) isolates. Fourteen (18.14%) strains were resistant to Streptomycin, 8 (4.65%) to Rifampicin, 11 (6.40%) to Isoniazid, 1 (0.58%) to Pyrazinamide and 2 (1.16%) to Ethambutol. Multidrug resistance was observed in 5 (2.91%) cases, of which resistance to Isoniazid and Rifampicin was present in 2 (1.16%) and their combination with other drugs in other 3 (1.74%) isolates.

Conclusions: Drug susceptibility pattern to antitubercular drugs is discussed and compared with studies from other centres.

Keywords: Antitubercular drugs; Drug resistance; Mycobacterium tuberculosis.

PubMed Disclaimer

References

    1. Eltringhas LJ, Wilson SM, Drobniewski FA. Evaluation of bacteriophage based assay (phage amplified biological assay) as a rapid screen for resistance to isoniazid, ethambutol, streptomycin, pyrazinamide, and ciprofloxacin among clinical isolates of Mycobacterium tuberculosis. J Clinic Microbial. 1993;37:3528–3532. - PMC - PubMed
    1. Pathania V, Almeida J, Kochi TB patients and private for profit health care providers in India. WHO\TB\97. 1997:223.
    1. Udwadia ZF. India. In: Davis PDO, editor. Clinical Tuberculosis. 2nd edition. Chapman & Hall; London: 1998. pp. 591–605.
    1. Jawahar MS. Multi drug resistant tuberculosis. ICMR bulletin. 1999;29:105–114.
    1. Paramasivan CN. An overview on drug resistant tuberculosis in India. Lung India. 1998;XVI:21–28.