Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;28(4):249-56.
doi: 10.1016/j.jsha.2015.12.005. Epub 2016 Jan 6.

Arterial stiffness in metabolic syndrome

Mona Adel  1 , Ayman ELSheikh  1 , Sameh Sameer  1 , Waiel Haseeb  1 , Eman ELSheikh  1 , Lamia Kheder  1
Affiliations

Arterial stiffness in metabolic syndrome

Mona Adel et al. J Saudi Heart Assoc. 2016 Oct.

Abstract

Arterial stiffness is increasingly recognized as an important determinant of cardiovascular risk and may be directly involved in the process of atherosclerosis. As atherosclerosis leads to increased arterial resistance and decrease the flow propagation speed within the arterial lumen, a similar decrease in aortic flow propagation with increased downstream resistance is detected, so aortic flow propagation velocity AVP was evaluated in many studies as a new parameter of aortic stiffness.

Aim: To measure arterial stiffness using the new parameter AVP and compare it to flow mediated dilatation FMD as a parameter of endothelial dysfunction in patients with metabolic syndrome MS.

Methods: AVP (assessed by transthoracic echocardiography) and FMD (assessed by brachial artery reactivity test) were measured in 100 patients with MS (Group 1) and were compared to 14 normal subjects (Group 2).

Results: Patients with MS had significantly lower values of AVP as compared to the normal subjects; 36 ± 5 cm/s vs 57 ± 5, p < 0.05, and lower FMD; 6% ± 1 vs 17 ± 3 p < 0.05 as well, there was significant correlations between AVP and FMD (r = 0.89, p < 0.001).

Conclusion: Transthoracic echocardiographic determination of AVP is a simple practical method and correlates well with FMD in patients with MS.

Keywords: ALT, alanine transaminase; AST, aspartate transaminase; AVP; AVP, aortic velocity propagation; Aortic propagation velocity; Arterial stiffness; CRP, C reactive protein; DBP, diastolic blood pressure; E/e′, filling pressure; EPF, epicardial fat; FBS, fasting blood sugar; FMD, flow mediated dilatation; HDL, high density lipoprotein; IVS, interventricular septum; Metabolic syndrome; SBP, systolic blood pressure; TC, total cholesterol; TG, triglycerides; UA, uric acid; WC, waist circumference.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Significant correlation between AVP and FMD. AVP = aortic velocity propagation; FMD = flow-mediated dilatation.
Figure 2
Figure 2
Color M-Mode at descending aorta from suprasternal area in a patient with metabolic syndrome. AVP = 24 cm/s. AVP = aortic velocity propagation.
Figure 3
Figure 3
Color M-Mode at descending aorta from suprasternal area in a normal subject. AVP = 52 cm/s. AVP = aortic velocity propagation.
See this image and copyright information in PMC

References

    1. Chobanian A.V., Bakris G.L., Black H.R., Cushman W.C., Green L.A., Izzo J.L., Jr. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289:2560–2572. - PubMed
    1. Lakatta E.G., Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a “set up” for vascular disease. Circulation. 2003;107:139–146. - PubMed
    1. Scuteri A., Najjar S.S., Muller D.C., Andres R., Hougaku H., Metter E.J. Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness. J Am Coll Cardiol. 2004;43:1388–1395. - PubMed
    1. Collins A.J., Li S., Gilbertson D.T., Liu J., Chen S.C., Herzog C.A. Chronic kidney disease and cardiovascular disease in the Medicare population. Kidney Int Suppl. 2003;87:S24–S31. - PubMed
    1. Tounian P., Aggoun Y., Dubern B., Varille V., Guy-Grand B., Sidi D. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet. 2001;358:1400–1404. - PubMed