Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 May;75(5):2512-5.
doi: 10.1073/pnas.75.5.2512.

Intraventricular administration of nerve growth factor induces ornithine decarboxylase in peripheral tissues of the rat

K Nagaiah, T Ikeno, J Lakshmanan, P MacDonnell, G Guroff

Intraventricular administration of nerve growth factor induces ornithine decarboxylase in peripheral tissues of the rat

K Nagaiah et al. Proc Natl Acad Sci U S A. 1978 May.

Abstract

Intraventricular administration of nerve growth factor causes an increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in liver, kidney, and adrenal as well as in brain itself. An increase in the concentration of corticosterone in the blood was also observed. Adrenalectomy, hypophysectomy, or pituitary stalk section inhibits the increase of ornithine decarboxylase activity in the peripheral tissues. Ornithine decarboxylase activity in the brain, however, responds to nerve growth factor in these animals. The data indicate that nerve growth factor causes an acitivation of the hypothalamo-hypophyseal endocrine system.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Biol Chem. 1977 Aug 25;252(16):5859-63 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Dec;72(12):4769-71 - PubMed
    1. J Biol Chem. 1976 Mar 25;251(6):1738-44 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4681-4 - PubMed
    1. Biochem Biophys Res Commun. 1978 Apr 14;81(3):941-6 - PubMed