Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Sep 29;128(13):1668-9.
doi: 10.1182/blood-2016-08-730622.

A tip of the cap to procoagulant platelets

Brian Storrie  1
Affiliations
Comment

A tip of the cap to procoagulant platelets

Brian Storrie. Blood. .

Abstract

In this issue of Blood, Podoplelova et al reveal how structural features of procoagulant platelets, generated in response to strong agonists, eg, thrombin and collagen-related peptides, provide an extensively folded surface area for the membrane-dependent assembly of tenase and prothrombinase complexes and subsequent thrombin generation. In brief, the structural features of a small, specialized region of the surface of procoagulant platelets, termed the “cap,” likely contribute strongly to localized amplification of coagulation in thrombosis.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
A “capped” procoagulant platelet as shown by differential interference contrast microscopy, fluorescence microscopy (green, factor IXa labeling), and in cartoon form. Scale bar, 5 μm. Micrographs are from Figure 2A in the article by Podoplelova et al. See the complete figure in the article by Podoplelova et al that begins on page 1745.
See this image and copyright information in PMC

Comment on

References

    1. Podoplelova NA, Sveshnikova AN, Kotova YN, et al. Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting. Blood. 2016;128(13):1745–1755. - PubMed
    1. Taylor RB, Duffus WP, Raff MC, de Petris S. Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by anti-immunoglobulin antibody. Nat New Biol. 1971;233(42):225–229. - PubMed
    1. Jackson SP, Schoenwaelder SM. Procoagulant platelets: are they necrotic? Blood. 2010;116(12):2011–2018. - PubMed
    1. Agbani EO, van den Bosch MT, Brown E, et al. Coordinated membrane ballooning and procoagulant spreading in human platelets. Circulation. 2015;132(15):1414–1424. - PubMed
    1. Battinelli EM. Procoagulant platelets: not just full of hot air. Circulation. 2015;132(15):1374–1376. - PubMed