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Review
. 2017 Feb;187(2):185-192.
doi: 10.1111/cei.12877. Epub 2016 Nov 1.

DNA methylation alterations in the pathogenesis of lupus

S H Chen  1 , Q L Lv  2 , L Hu  2 , M J Peng  2 , G H Wang  1 , B Sun  2
Affiliations
Review

DNA methylation alterations in the pathogenesis of lupus

S H Chen et al. Clin Exp Immunol. 2017 Feb.

Abstract

Although lupus is, by definition, associated with genetic and immunological factors, its molecular mechanisms remain unclear. The up-to-date research findings point out that various genetic and epigenetic factors, especially gene-specific and site-specific methylation, are believed to contribute to the initiation and development of systemic lupus erythematosus (SLE). This review presents and summarizes the association between abnormal DNA methylation of immune-related cells and lupus-like diseases, as well as the possible mechanisms of immune disorder caused by DNA methylation, aiming at a better understanding of the roles of aberrant DNA methylation in the initiation and development of certain forms of lupus and providing a new insight into promising therapeutic regimens in lupus-like diseases.

Keywords: DNA methylation; immune-related cells; lupus-like diseases; systemic lupus erythematosus.

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