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Review
. 2017 May;19(5):489-503.
doi: 10.1080/10286020.2016.1235562. Epub 2016 Oct 3.

Synthesis and antioxidant activity of curcumin analogs

Qu-Tong Zheng  1   2 , Ze-Hua Yang  1   2 , Liu-Ying Yu  1   2 , Yu-Yan Ren  1   2 , Qiu-Xia Huang  1   2 , Qiu Liu  1   2   3 , Xiang-Yu Ma  1   2 , Zi-Kang Chen  1   2   3 , Zong-Bao Wang  1   2 , Xing Zheng  1   2
Affiliations
Review

Synthesis and antioxidant activity of curcumin analogs

Qu-Tong Zheng et al. J Asian Nat Prod Res. 2017 May.

Abstract

Numerous biological activities including antioxidant, antitumor, anti-inflammation, and antivirus of the natural product curcumin were reported. However, the clinical application of it was significantly limited by its instability, poor solubility, less body absorbing, and low bioavailability. This review focuses on the structure modification and antioxidant activity evaluation of curcumin. To study the structure-activity relationship (SAR), five series of curcumin analogs were synthesized and their antioxidant activity were evaluated in vitro. The results showed that electron-donating groups, especially the phenolic hydroxyl group are an essential component to improve the antioxidant activity.

Keywords: Curcumin; antioxidant activity; structure modification; structure–activity relationship.

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