Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2017 Feb;20(3):549-555.
doi: 10.1017/S1368980016002597. Epub 2016 Oct 3.

Effects of initiating moderate wine intake on abdominal adipose tissue in adults with type 2 diabetes: a 2-year randomized controlled trial

Rachel Golan  1 , Ilan Shelef  2 , Elad Shemesh  2 , Yaakov Henkin  2 , Dan Schwarzfuchs  3 , Yftach Gepner  1 , Ilana Harman-Boehm  2 , Shula Witkow  1 , Michael Friger  1 , Yoash Chassidim  2 , Idit F Liberty  2 , Benjamin Sarusi  3 , Dana Serfaty  1 , Nitzan Bril  1 , Michal Rein  1 , Noa Cohen  1 , Sivan Ben-Avraham  1 , Uta Ceglarek  4 , Michael Stumvoll  4 , Matthias Blüher  4 , Joachim Thiery  4 , Meir J Stampfer  5 , Assaf Rudich  1 , Iris Shai  1
Affiliations
Randomized Controlled Trial

Effects of initiating moderate wine intake on abdominal adipose tissue in adults with type 2 diabetes: a 2-year randomized controlled trial

Rachel Golan et al. Public Health Nutr. 2017 Feb.

Abstract

Objective: To generate evidence-based conclusions about the effect of wine consumption on weight gain and abdominal fat accumulation and distribution in patients with type 2 diabetes.

Design: In the 2-year randomized controlled CASCADE (CArdiovaSCulAr Diabetes & Ethanol) trial, patients following a Mediterranean diet were randomly assigned to drink 150 ml of mineral water, white wine or red wine with dinner for 2 years. Visceral adiposity and abdominal fat distribution were measured in a subgroup of sixty-five participants, using abdominal MRI.

Setting: Ben-Gurion University of the Negev, Soroka-Medical Center and the Nuclear Research Center Negev, Israel.

Subjects: Alcohol-abstaining adults with well-controlled type 2 diabetes.

Results: Forty-eight participants (red wine, n 27; mineral water, n 21) who completed a second MRI measurement were included in the 2-year analysis. Similar weight losses (sd) were observed: red wine 1·3 (3·9) kg; water 1·0 (4·2) kg (P=0·8 between groups). Changes (95 % CI) in abdominal adipose-tissue distribution were similar: red wine, visceral adipose tissue (VAT) -3·0 (-8·0, 2·0) %, deep subcutaneous adipose tissue (DSAT) +5·2 (-1·1, 11·6) %, superficial subcutaneous adipose tissue (SSAT) -1·9 (-5·0, 1·2) %; water, VAT -3·2 (-8·9, 2·5) %, DSAT +2·9 (-2·8, 8·6) %, SSAT -0·15 (-3·3, 2·9) %. No changes in antidiabetic medication and no substantial changes in energy intake (+126 (sd 2889) kJ/d (+30·2 (sd 690) kcal/d), P=0·8) were recorded. A 2-year decrease in glycated Hb (β=0·28, P=0·05) was associated with a decrease in VAT.

Conclusions: Moderate wine consumption, as part of a Mediterranean diet, in persons with controlled diabetes did not promote weight gain or abdominal adiposity.

Trial registration: ClinicalTrials.gov NCT00784433.

Keywords: Abdominal adipose tissue; MRI; Mediterranean diet; Type 2 diabetes; Wine.

PubMed Disclaimer

References

    1. Schröder H, Morales-Molina JA, Bermejo S et al.. (2007) Relationship of abdominal obesity with alcohol consumption at population scale. Eur J Nutr 46, 369–376. - PubMed
    1. Dallongeville J, Marécaux N, Ducimetière P et al.. (1998) Influence of alcohol consumption and various beverages on waist girth and waist-to-hip ratio in a sample of French men and women. Int J Obes Relat Metab Disord 22, 1178–1183. - PubMed
    1. Kimokoti RW, Gona P, Zhu L et al.. (2012) Dietary patterns of women are associated with incident abdominal obesity but not metabolic syndrome. J Nutr 142, 1720–1727. - PMC - PubMed
    1. Kanerva N, Kaartinen NE, Schwab U et al.. (2013) Adherence to the Baltic Sea diet consumed in the Nordic countries is associated with lower abdominal obesity. Br J Nutr 109, 520–528. - PubMed
    1. Greenfield JR, Samaras K, Jenkins AB et al.. (2003) Moderate alcohol consumption, dietary fat composition, and abdominal obesity in women: evidence for gene–environment interaction. J Clin Endocrinol Metab 88, 5381–5386. - PubMed

Publication types

Substances

Associated data