Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Oct;16(5):481-485.
doi: 10.7861/clinmedicine.16-5-481.

Adverse drug reactions

Jamie J Coleman  1 , Sarah K Pontefract  2
Affiliations
Review

Adverse drug reactions

Jamie J Coleman et al. Clin Med (Lond). 2016 Oct.

Abstract

Adverse drug reactions (ADRs) remain a challenge in modern healthcare, particularly given the increasing complexity of therapeutics, an ageing population and rising multimorbidity. This article summarises some of the key facts about ADRs and explores aspects relating to their prevention, diagnosis, reporting and management in current clinical practice.

Keywords: Adverse drug reactions; adverse drug reaction reporting systems; clinical pharmacology; drug-related side effects and adverse reactions; pharmacovigilance.

PubMed Disclaimer

References

    1. Aronson JK. Ferner RE. Clarification of terminology in drug safety. Drug Saf. 2005;28:851–70. - PubMed
    1. European Directive 2010/84/EU of 15 December 2010 amending, as regards pharmacovigilance, Directive 2001/83/EC on the Community code relating to medicinal products for human use
    1. Bates DW. Leape LL. Petrycki S. Incidence and preventability of adverse drug events in hospitalized adults. J Gen Intern Med. 1993;8:289–94. - PubMed
    1. Lazarou J. Pomeranz BH. Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998;279:1200–5. - PubMed
    1. Pirmohamed M. James S. Meakin S, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004;329:15–9. - PMC - PubMed

MeSH terms