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Meta-Analysis
. 2017 Jan;41(1):96-101.
doi: 10.1038/ijo.2016.175. Epub 2015 Oct 4.

Weight losses with low-energy formula diets in obese patients with and without type 2 diabetes: systematic review and meta-analysis

W S Leslie  1 , R Taylor  2 , L Harris  3 , M E J Lean  1
Affiliations
Meta-Analysis

Weight losses with low-energy formula diets in obese patients with and without type 2 diabetes: systematic review and meta-analysis

W S Leslie et al. Int J Obes (Lond). 2017 Jan.

Erratum in

Abstract

Aim: To provide a systematic review, of published data, to compare weight losses following very low calorie (<800 kcal per day VLCD) or low-energy liquid-formula (>800 kcal per day LELD) diets, in people with and without type 2 diabetes mellitus (T2DM).

Methods: Systematic electronic searches of Medline (1946-2015) and Embase (1947-2015) to identify published studies using formula total diet replacement diets (VLCD/LELD). Random effects meta-analysis using weighted mean difference (WMD) in body weight between groups (with and without diabetes) as the summary estimate.

Results: Final weight loss, in the five included studies, weighted for study sizes, (n=569, mean BMI=35.5-42.6 kg/m2), was not significantly different between participants with and without T2DM: -1.2 kg; 95% CI: -4.1 to 1.6 kg). Rates of weight loss were also similar in the two groups -0.6 kg per week (T2DM) and 0.5 kg per week (no diabetes), and for VLCD (<800 kcal per day) and LELD (>800 kcal per day).

Conclusions: Weight losses with liquid-formula diets are very similar for VLCD and LELD and for obese subjects with or without T2DM. They can potentially achieve new weight loss/ maintenance targets of >15-20% for people with severe and medically complicated obesity.

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Conflict of interest statement

WSL, MEJL and RT are currently engaged on the Diabetes Remission Clinical Trial (DiRECT) funded by Diabetes UK with additional support in kind from Cambridge Weight Plan. MEJL and RT have received support related to the use of formula diet products from Cambridge Weight Plan and from Nestle.

Figures

Figure 1
Figure 1
Flowchart of progress of papers through the review.
Figure 2
Figure 2
Meta-analysis (WMD) of studies comparing weight losses in those with type 2 diabetes and non-diabetic subjects.
See this image and copyright information in PMC

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MeSH terms