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. 2016 Oct;12(4):2451-2456.
doi: 10.3892/ol.2016.4999. Epub 2016 Aug 11.

Ultrasonic features of papillary thyroid microcarcinoma coexisting with a thyroid abnormality

Bo Li  1 , Yaqiong Zhang  2 , Ping Yin  1 , Jian Zhou  1 , Tian'an Jiang  3
Affiliations

Ultrasonic features of papillary thyroid microcarcinoma coexisting with a thyroid abnormality

Bo Li et al. Oncol Lett. 2016 Oct.

Abstract

The present study aimed to investigate the value of ultrasonography in the diagnosis of papillary thyroid microcarcinoma (PTMC) coexisting with a thyroid abnormality, and to improve the accuracy of PTMC diagnosis. The ultrasonic features of 38 PTMC nodules coexisting with a thyroid abnormality and 56 thyroid benign nodules, obtained by surgical resection and confirmed by pathological analysis, were retrospectively analyzed. All masses were ≤ 1.0 cm in diameter. Ultrasonic features that were analyzed included the shape, aspect ratio, boundary, margin, echo, uniformity, presence or absence of microcalcification and enlargement of the lymph nodes, as well as the blood flow of the nodules. Furthermore, the sensitivity, specificity and accuracy of ultrasonography for the diagnosis of PTMC were obtained. The following ultrasonic features of thyroid nodules were significantly (P<0.05) associated with PTMC coexisting with a thyroid abnormality: An irregular shape; an aspect ratio of ≥ 1; an unclear boundary; blurred margins; internal heterogeneous hypoechogenicity; and microcalcification. Therefore, thyroid nodules with these ultrasonic characteristics coexisting with a thyroid abnormality may be suspected as malignant PTMC. The present study demonstrated that ultrasound-guided biopsies are necessary to prevent misdiagnosis of PTMC. The sensitivities of enlarged neck lymph nodes and abundant blood flow are so low that they may be considered as references for the differentiation of PTMC from benign nodules.

Keywords: papillary thyroid microcarcinoma; thyroid abnormality; ultrasonic diagnosis.

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Figures

Figure 1.
Figure 1.
An ultrasound scan of the right thyroid lobe of a patient with papillary thyroid microcarcinoma and coexisting thyroid disease shows a hypoechoic nodule.
Figure 2.
Figure 2.
An ultrasound scan of the left thyroid lobe of a patient with papillary thyroid microcarcinoma and a coexisting thyroid disease shows a hyperechoic nodule.
Figure 3.
Figure 3.
An ultrasound scan of the right thyroid lobe of a patient with papillary thyroid microcarcinoma and coexisting hyperthyroidism shows a nodule with microcalcification.
Figure 4.
Figure 4.
An ultrasound scan of the right thyroid lobe of a patient with papillary thyroid microcarcinoma and coexisting hyperthyroidism.
Figure 5.
Figure 5.
An ultrasound scan of the right thyroid lobe of a patient with papillary thyroid microcarcinoma and coexisting Hashimoto thyroiditis shows a nodule with microcalcification.
Figure 6.
Figure 6.
An ultrasound scan of the left thyroid lobe of a patient with papillary thyroid microcarcinoma and coexisting Hashimoto thyroiditis.
Figure 7.
Figure 7.
An ultrasound scan of the left thyroid lobe of a patient with papillary thyroid microcarcinoma shows a nodule with a secondary blood supply.
See this image and copyright information in PMC

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