Current Status and Perspective of Immunotherapy in Gastrointestinal Cancers
- PMID: 27698896
- PMCID: PMC5039380
- DOI: 10.7150/jca.16208
Current Status and Perspective of Immunotherapy in Gastrointestinal Cancers
Abstract
Cancer immunotherapy is at dawn of the Renaissance after the Medieval Dark Ages. Recent advances of understanding tumor immunology and molecular drug development are leading us to the epoch of cancer immunotherapy. Some types of immunotherapy have shown to provide survival benefit for patients with solid tumors such as malignant melanoma, renal cell carcinoma, or non-small cell lung cancer. Several studies have suggested that immune checkpoint inhibition might be effective in some patients with gastrointestinal cancers. However, the era of cancer immunotherapy in gastrointestinal cancers is still in an inchoate stage. Here we briefly review the current status and perspective of immunotherapeutic approaches in patients with gastrointestinal cancers.
Keywords: Cancer vaccines; Gastrointestinal cancers; Immune checkpoint inhibitors; Immunotherapy; Review..
Conflict of interest statement
The authors have declared that no competing interest exists.
References
-
- Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M. et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN2012. Int J Cancer. 2015;136:E359–86. - PubMed
-
- Slankard-Chahinian M, Holland JF, Gordon RE, Becker J, Ohnuma T. Adoptive autoimmunotherapy. Cytotoxic effect of an autologous long-term T-cell line on malignant melanoma. Cancer. 1984;53:1066–72. - PubMed
-
- Parkinson DR, Abrams JS, Wiernik PH, Rayner AA, Margolin KA, Van Echo DA. et al. Interleukin-2 therapy in patients with metastatic malignant melanoma: a phase II study. J Clin Oncol. 1990;8:1650–6. - PubMed
-
- Flaherty LE, Atkins M, Sosman J, Weiss G, Clark JI, Margolin K. et al. Outpatient biochemotherapy with interleukin-2 and interferon alfa-2b in patients with metastatic malignant melanoma: results of two phase II cytokine working group trials. J Clin Oncol. 2001;19:3194–202. - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources