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Case Reports
. 2017 Apr;32(2):275-276.
doi: 10.1177/0884533616670380. Epub 2016 Oct 5.

Reversible Facial Hyperpigmentation Associated With Vitamin B12 Deficiency

Leeda Tayem  1 , Noureddine Litaiem  1 , Mariem Jones  1 , Faten Zeglaoui  1
Affiliations
Case Reports

Reversible Facial Hyperpigmentation Associated With Vitamin B12 Deficiency

Leeda Tayem et al. Nutr Clin Pract. 2017 Apr.

Abstract

Vitamin B12 (cobalamin) deficiency is common in developing countries. Its dermatologic manifestations include hair and nail changes and glossitis. Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported. Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas. We report a rare case of reversible melasma-like cutaneous hyperpigmentation associated with pernicious anemia and discuss the possible mechanisms of this association.

Keywords: cobalamin; hyperpigmentation; pernicious anemia; vitamin B12; vitamin B12 deficiency.

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