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. 2016 Nov 16;27(11):2597-2600.
doi: 10.1021/acs.bioconjchem.6b00541. Epub 2016 Oct 12.

Novel Catalyst System for Suzuki-Miyaura Coupling of Challenging DNA-Linked Aryl Chlorides

Yun Ding  1 , Jennifer L DeLorey  1 , Matthew A Clark  1
Affiliations

Novel Catalyst System for Suzuki-Miyaura Coupling of Challenging DNA-Linked Aryl Chlorides

Yun Ding et al. Bioconjug Chem. .

Abstract

A novel Pd catalyst system, [(t-Bu)2P(OH)]2PdCl2 (POPd) with the ligand sodium 2'-(dicyclohexylphosphino)-2,6-dimethoxy-[1,1'-biphenyl]-3-sulfonate, is reported. It effectively catalyzes the Suzuki-Miyaura coupling of challenging phenyl chlorides and pyrimidinyl chlorides that are covalently linked to a double-stranded DNA-template with various boronic acids/esters.

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