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. 2016 Oct 5;11(10):e0162575.
doi: 10.1371/journal.pone.0162575. eCollection 2016.

Influenza Pandemics and Tuberculosis Mortality in 1889 and 1918: Analysis of Historical Data from Switzerland

Kathrin Zürcher  1 , Marcel Zwahlen  1 , Marie Ballif  1 , Hans L Rieder  2 , Matthias Egger  1 , Lukas Fenner  1   3   4
Affiliations

Influenza Pandemics and Tuberculosis Mortality in 1889 and 1918: Analysis of Historical Data from Switzerland

Kathrin Zürcher et al. PLoS One. .

Abstract

Background: Tuberculosis (TB) mortality declined in the northern hemisphere over the last 200 years, but peaked during the Russian (1889) and the Spanish (1918) influenza pandemics. We studied the impact of these two pandemics on TB mortality.

Methods: We retrieved historic data from mortality registers for the city of Bern and countrywide for Switzerland. We used Poisson regression models to quantify the excess pulmonary TB (PTB) mortality attributable to influenza.

Results: Yearly PTB mortality rates increased during both influenza pandemics. Monthly influenza and PTB mortality rates peaked during winter and early spring. In Bern, for an increase of 100 influenza deaths (per 100,000 population) monthly PTB mortality rates increased by a factor of 1.5 (95%Cl 1.4-1.6, p<0.001) during the Russian, and 3.6 (95%Cl 0.7-18.0, p = 0.13) during the Spanish pandemic. Nationally, the factor was 2.0 (95%Cl 1.8-2.2, p<0.001) and 1.5 (95%Cl 1.1-1.9, p = 0.004), respectively. We did not observe any excess cancer or extrapulmonary TB mortality (as a negative control) during the influenza pandemics.

Conclusions: We demonstrate excess PTB mortality during historic influenza pandemics in Switzerland, which supports a role for influenza vaccination in PTB patients in high TB incidence countries.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Yearly trends in pulmonary tuberculosis (PTB), influenza, and pneumonia mortality per 100,000 people during the Russian and Spanish influenza pandemics in the city of Bern (A and C) and in Switzerland (B and D).
Fig 2
Fig 2. Seasonal trends in pulmonary tuberculosis (PTB) and influenza monthly mortality per 100,000 population.
Fig 3
Fig 3. Cross-sectional mortality rates per 100,000 population of pulmonary tuberculosis (PTB) and influenza (including pneumonia and acute respiratory diseases) in Bern (A and C) and Switzerland (B and D) by age, during the influenza pandemics of 1889–1894 and 1918–1920.
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