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. 2016 Oct;57(10):1081-1086.

Diagnostic value of creatine kinase activity in canine cerebrospinal fluid

Alexandra Ferreira  1
Affiliations

Diagnostic value of creatine kinase activity in canine cerebrospinal fluid

Alexandra Ferreira. Can Vet J. 2016 Oct.

Abstract
in English, French

This study aimed to determine whether creatine kinase (CK) activity in cerebrospinal fluid (CSF) has diagnostic value for various groups of neurological conditions or for different anatomical areas of the nervous system (NS). The age, breed, results of CSF analysis, and diagnosis of 578 canine patients presenting with various neurological conditions between January 2009 and February 2015 were retrospectively collected. The cases were divided according to anatomical areas of the nervous system, i.e., brain, spinal cord, and peripheral nervous system, and into groups according to the nature of the condition diagnosed: vascular, immune/inflammatory/infectious, traumatic, toxic, anomalous, metabolic, idiopathic, neoplastic, and degenerative. Statistical analysis showed that CSF-CK alone cannot be used as a diagnostic tool and that total proteins in the CSF and red blood cells (RBCs) do not have a significant relationship with the CSF-CK activity. CSF-CK did not have a diagnostic value for different disease groups or anatomical areas of the nervous system.

Valeur diagnostique de l’activité de la créatine kinase dans le liquide céphalorachidien canin. Cette étude a visé à déterminer si l’activité de la créatine kinase (CK) dans le liquide céphalorachidien (LCR) avait une valeur diagnostique pour les divers groupes d’affections neurologiques ou pour les différentes régions anatomiques du système nerveux (SN). L’âge, la race, les résultats de l’analyse LCR et le diagnostic de 578 patients canins présentant diverses affections neurologiques, entre janvier 2009 et février 2015, ont été recueillis rétrospectivement. Les cas ont été répartis selon les régions anatomiques du système nerveux, c.-à-d., le cerveau, la moelle épinière et le système nerveux périphérique et selon les groupes conformément à la nature de l’affection diagnostiquée: vasculaire, immunitaire/inflammatoire/infectieuse, traumatique, toxique, anormale, métabolique, idiopathique, néoplasique et dégénérative. L’analyse statistique a démontré que l’analyse LCR-CK ne peut pas être utilisée à elle seule comme outil de diagnostic et que les protéines totales dans le LCR et les érythrocytes n’ont pas un impact important sur l’activité LCR-CK. L’analyse LCR-CK n’a pas eu une valeur diagnostique pour les divers groupes de maladie ou les différentes régions du système nerveux.(Traduit par Isabelle Vallières).

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Figures

Figure 1
Figure 1
Distribution of log CSF-CK activity between anatomical area and nature of the condition, showing no correlation between the variables. 1 — anomalous; 2 — degenerative; 3 — idiopathic; 4 — immune/inflammatory/infectious; 5 — metabolic; 6 — neoplastic; 7 — toxic; 8 — traumatic; 9 — vascular.
Figure 2
Figure 2
Area for normal range of (log) CSF-CK activity between anatomical area and nature of the condition, showing scattered values and hence no specific reference range for any of the conditions: 1 — anomalous; 2 — degenerative; 3 — idiopathic; 4 — immune/inflammatory/infectious; 5 — metabolic; 6 — neoplastic; 7 — toxic; 8 — traumatic; 9 — vascular.
See this image and copyright information in PMC

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