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. 2015 Jun;2(2):78-79.
doi: 10.5152/eurjrheum.2015.0072. Epub 2015 Mar 31.

Successful treatment of Acrodermatitis continua of Hallopeau associated with psoriatic arthritis with adalimumab

Salima Lefkir  1 , Samy Slimani  2 , Nadjia Brahimi  1 , Aicha Ladjouze-Rezig  1
Affiliations

Successful treatment of Acrodermatitis continua of Hallopeau associated with psoriatic arthritis with adalimumab

Salima Lefkir et al. Eur J Rheumatol. 2015 Jun.

Abstract

Acrodermatitis continua of Hallopeau (ACH) is a rare form of pustular psoriasis, mainly affecting distal phalanges of hands and feet. Many therapeutic options exist; however, it tends to be resistant to treatment. We report a 26-year-old man presented with a very severe psoriatic arthritis associated with ACH. Although this patient was resistant to a first line treatment (glucocorticoids and methotrexate), a rapid and dramatic improvement was observed after adalimumab was introduced. The effectiveness and tolerance of the treatment were maintained during the 12-month period of follow-up. This is the first report of the efficacy of adalimumab on ACH in a patient presented with psoriatic arthropathy.

Keywords: Acrodermatitis continua of Hallopeau; adalimumab; psoriatic arthritis.

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Figures

Figure 1
Figure 1
Typical Hallopeau pustules on the face
Figure 2
Figure 2
Characteristic Hallopeau lesions on fingers
Figure 3
Figure 3
Rapid improvement of cutaneous lesions on the face after the initiation of adalimumab treatment
Figure 4
Figure 4
Improvement of cutaneous lesions on the fingers after the initiation of adalimumab treatment
See this image and copyright information in PMC

References

    1. Gluckman SJ, Heyman W. Diagnosis: acrodermatitis continua of Hallopeau. Clin Infect Dis. 2001;32:431–505. - PubMed
    1. Kiszewski AE, De Villa D, Scheibel I, Ricachnevsky N. An infant with acrodermatitis continua of Hallopeau: successful treatment with thalidomide and UVB therapy. Pediatr Dermatol. 2009;26:105–6. http://dx.doi.org/10.1111/j.1525-1470.2008.00838.x. - DOI - PubMed
    1. Brill TJ, Elshorst-Schmidt T, Valesky EM, Kaufmann R, Thaçi D. Successful treatment of acrodermatitis continua of Hallopeau with sequential combination of calcipotriol and tacrolimus ointments. Dermatology. 2005;211:351–5. http://dx.doi.org/10.1159/000088507. - DOI - PubMed
    1. van Dooren-Greebe RJ, van de Kerkhof PC, Chang A, Happle R. Acitretin monotherapy in acrodermatitis continua Hallopeau. Acta Derm Venereol. 1989;69:344–6. - PubMed
    1. Wong VK, Lebwohl MG. Treatment of psoriatic arthritis with etanercept, a tumour necrosis factor antagonist. Expert Opin Biol Ther. 2005;5:1505–13. http://dx.doi.org/10.1517/14712598.5.11.1505. - DOI - PubMed

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