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. 2016 Oct 6;52(82):12195-12198.
doi: 10.1039/c6cc06914b.

Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

Alessandra Augurusa  1 , Meera Mehta  1 , Manuel Perez  1 , Jiangtao Zhu  1 , Douglas W Stephan  1
Affiliations

Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

Alessandra Augurusa et al. Chem Commun (Camb). .

Abstract

A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.

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