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. 2017 Apr;125(4):602-607.
doi: 10.1289/EHP302. Epub 2016 Oct 7.

Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis

Ya-Ru Yang  1 , Yung-Ming Chen, Szu-Ying Chen, Chang-Chuan Chan
Affiliations

Associations between Long-Term Particulate Matter Exposure and Adult Renal Function in the Taipei Metropolis

Ya-Ru Yang et al. Environ Health Perspect. 2017 Apr.

Abstract

Background: Studies on the effect of air pollutions on kidney diseases are still limited.

Objective: We aimed to investigate the associations between particulate matter (PM) exposures and renal function among adults.

Methods: We recruited 21,656 adults as participants from 2007 to 2009. The Taiwanese Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to derive the estimated glomerular filtration rate (eGFR). Subjects with an eGFR lower than 60 mL/min/1.73 m2 were defined as having chronic kidney disease (CKD). Land use regression (LUR) models were used to estimate individual exposures to PM with an aerodynamic diameter < 10 μm (PM10), coarse particles (PMCoarse), fine particles (PM2.5), and PM2.5Absorbance. Generalized linear and logistic regression models were used to estimate the associations between PM exposure and renal function.

Results: An IQR increase in PM10 (5.83 μg/m3) was negatively associated with eGFR by -0.69 (95% CI: -0.89, -0.48) mL/min/1.73 m2 and positively associated with the prevalence of CKD with adjusted OR = 1.15 (95% CI: 1.07, 1.23). An IQR increase in PMCoarse (6.59 μg/m3) was significantly associated with lower eGFR by -1.07 (95% CI: -1.32, -0.81) mL/min/1.73 m2 and CKD with OR = 1.26 (95% CI: 1.15, 1.38). In contrast, neither outcome was significantly associated with PM2.5 or PM2.5Absorbance. Stratified analyses indicated that associations of CKD with both PM10 and PMCoarse were limited to participants < 65 years of age, and were stronger (for PM10) or limited to (PMCoarse) women. Associations also appeared to be stronger in those without (vs. with) hypertension, and in normal versus overweight participants.

Conclusions: Exposure during the previous year to PM10 and PMCoarse, but not PM2.5 or PM2.5Absorbance, was associated with reduced renal function among Taiwanese adults.

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Conflict of interest statement

The authors declare that they have no actual or potential competing financial interests.

Figures

Figure 1
Figure 1
The odds of CKD for PM10 and PMCoarse exposures stratified by age, sex, diabetes mellitus, hyperlipidemia, hypertension, overweight, distance to major road, smoking status, alcohol consumption, and education level among the 21,656 participants of New Taipei City.
Figure 2
Figure 2
The odds of CKD for PM2.5 and PM2.5Absorbance exposures stratified by age, sex, diabetes mellitus, hyperlipidemia, hypertension, overweight, distance to major road, smoking status, alcohol consumption, and education level among the 21,656 participants of New Taipei City.
See this image and copyright information in PMC

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