Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Apr 28;3(5):1304-1310.
doi: 10.3390/ph3051304.

The Role of Non-Steroidal Anti-Inflammatory Drugs in Renal Colic

Kim Davenport  1 , Elizabeth Waine  2
Affiliations
Review

The Role of Non-Steroidal Anti-Inflammatory Drugs in Renal Colic

Kim Davenport et al. Pharmaceuticals (Basel). .

Abstract

NSAIDs provide optimal analgesia in renal colic due to the reduction in glomerular filtration and renal pelvic pressure, ureteric peristalsis and ureteric oedema. Prevention of glomerular afferent arteriolar vasodilatation renders these patients at risk of renal impairment. NSAIDs have the additional benefit of reducing the number of new colic episodes and preventing subsequent readmission to hospital. Despite recent work promoting the use of pharmacological agents to improve stone passage rates, NSAIDs do not appear to reduce the time to stone passage or increase the likelihood of stone passage in renal colic.

Keywords: Non-steroidal anti-inflammatory drugs; renal colic; ureteric stone.

PubMed Disclaimer

Figures

Figure 1
Figure 1
NSAIDs and their mechanism of action
See this image and copyright information in PMC

References

    1. Coll D.M., Varanelli M.J., Smith R.C. Relationship of spontaneous stone passage of ureteral calculi to stone size and location as revealed by unenhanced helical CT. Am. J. Roentgenol. 2002;178:101–103. - PubMed
    1. Miller O.F., Kane C.J. Time to stone passage for observed ureteral calculi: A guide for patient education. J. Urol. 1999;162:688–691. - PubMed
    1. Painter D.J., Keeley F.X., Jr. New concepts in the treatment of ureteral calculi. Curr. Opin. Urol. 2001;11:373–378. - PubMed
    1. Crowley A.R., Byrne J.C., Darracott Vaughan E., Marion D.N. The effect of acute obstruction on ureteral function. J. Urol. 1990;143:596–599. - PubMed
    1. Perlmutter A., Miller L., Trimble L.A., Marion D.N., Vaughan E.D., Jr., Felson D. Toradel, an NSAID used for renal colic, decreases renal perfusion and ureteral pressure in a canine model of unilateral ureteral obstruction. J. Urol. 1993;149:926–930. - PubMed

LinkOut - more resources