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Randomized Controlled Trial
. 2016 Oct 3;15(1):141.
doi: 10.1186/s12933-016-0457-7.

A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics

Katherine E Beaney  1 , Claire E Ward  2 , Dauda A S Bappa  1 , Nadine McGale  3 , Anna K Davies  3 , Shashivadan P Hirani  3 , KaWah Li  1 , Philip Howard  1 , Dwaine R Vance  2 , Martin A Crockard  2 , John V Lamont  2 , Stanton Newman  3 , Steve E Humphries  4
Affiliations
Randomized Controlled Trial

A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics

Katherine E Beaney et al. Cardiovasc Diabetol. .

Abstract

Background: The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits.

Methods: Ten-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randox's Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185).

Results: Overall, 10-year CHD risk ranged from 2-72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the CoRDia SMI plus risk group (n = 66) (p = 0.80) and a sample of UK healthy men (n = 1360). The GS was also associated with LDL-cholesterol (p = 0.05) and family history (p = 0.03) in a sample of UK healthy men (n = 1360).

Conclusions: CHD risk is high in this group of T2D subjects. The risk array is an accurate genotyping assay, and is suitable for estimating an individual's genetic CHD risk. Trial registration This study has been registered at ClinicalTrials.gov; registration identifier NCT01891786.

Keywords: Coronary heart disease; Gene score; Risk prediction; Type 2 diabetes; UKPDS score.

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Figures

Fig. 1
Fig. 1
Distribution of a UKPDS risk score in CoRDia participants (n = 210*) and b Combined risk score (UKPDS plus genetic risk) in CoRDia SMI plus risk results group (n = 70)
Fig. 2
Fig. 2
Distribution of risk alleles in a UK healthy men (n = 1360) and b CoRDia participants of Caucasian ethnicity in the SMI plus risk results arm (n = 66)*
Fig. 3
Fig. 3
Boxplot of gene score in UK healthy men and the CoRDia SMI plus risk results arm. The mean weighted gene score for each group is marked in red (horizontal line represents the median) and these were compared using a t test (p = 0.80). Non-Caucasian participants were removed from the CoRDia SMI plus risk results profile group. The number of participants in each was as follows, NPHSII n = 1360 and CoRDia plus risk results n = 66
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