Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep 30;15(1):170.
doi: 10.1186/s12944-016-0343-z.

The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women

Yanmei Wang  1 , Zhan Lu  1 , Jingxiao Zhang  1 , Yang Yang  2 , Jing Shen  3 , Xiaoming Zhang  4 , Yongyan Song  5
Affiliations

The APOA5 rs662799 polymorphism is associated with dyslipidemia and the severity of coronary heart disease in Chinese women

Yanmei Wang et al. Lipids Health Dis. .

Abstract

Background: The APOA5 rs662799 polymorphism has been widely reported regarding its associations with the plasma lipid levels and the occurrence of coronary heart disease (CHD), whereas its relationship with the severity of CHD has not yet been explored.

Methods: Four hundred and seventy-eight angiografically defined subjects (325 CHD patients and 153 CHD-free controls) were enrolled in this study. The rs662799 polymorphism was genotyped, and the fasting lipid data were collected for all participants. The severity of CHD was evaluated for the CHD patients by using Gensini scores.

Results: The variant C allele of the rs662799 polymorphism was associated with lower levels of HDL-C in CHD-free women, and higher levels of TG and TG/HDL-C in women with CHD (P < 0.05 for all). The C allele was associated with higher prevalence of dyslipidemia and higher levels of Gensini scores only in women (P < 0.05 for both), but not in men. Multivariate linear regression analysis showed that the rs662799 polymorphism was independently associated with the Gensini scores in women after adjustment for other potential CHD risk factors (Beta = 0.157, 95 % CI: 0.017-0.298, P = 0.028).

Conclusion: Our data indicate that the rs662799 polymorphism is associated with dyslipidemia and the severity of CHD in Chinese women.

Keywords: APOA5; Coronary heart disease; Lipid; Severity; rs662799.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
The Gensini score levels of the CHD patients according to the APOA5 rs662799 genotypes. The Gensini score levels were significantly different among the women with different rs662799 genotypes (P < 0.05)
See this image and copyright information in PMC

References

    1. Bi Y, Jiang Y, He J, Xu Y, Wang L, Xu M, et al. Status of cardiovascular health in Chinese adults. J Am Coll Cardiol. 2015;65:1013–25. doi: 10.1016/j.jacc.2014.12.044. - DOI - PubMed
    1. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case–control study. Lancet. 2004;364:937–52. doi: 10.1016/S0140-6736(04)17018-9. - DOI - PubMed
    1. Simpson HC, Mann JI, Meade TW, Chakrabarti R, Stirling Y, Woolf L. Hypertriglyceridaemia and hypercoagulability. Lancet. 1983;1:786–90. doi: 10.1016/S0140-6736(83)91849-4. - DOI - PubMed
    1. Lange LA, Willer CJ, Rich SS. Recent developments in genome and exome-wide analyses of plasma lipids. Curr Opin Lipidol. 2015;26:96–102. doi: 10.1097/MOL.0000000000000159. - DOI - PubMed
    1. Gombojav B, Lee SJ, Kho M, Song YM, Lee K, Sung J. Multiple susceptibility loci at chromosome 11q23.3 are associated with plasma triglyceride in East Asians. J Lipid Res. 2016;57:318–24. - PMC - PubMed

MeSH terms

LinkOut - more resources