Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Sep 30;17(1):202.
doi: 10.1186/s13059-016-1069-y.

DNA replication stress: a source of APOBEC3B expression in breast cancer

David W Cescon  1   2   3 , Benjamin Haibe-Kains  4   5   6   7
Affiliations
Comment

DNA replication stress: a source of APOBEC3B expression in breast cancer

David W Cescon et al. Genome Biol. .

Abstract

APOBEC cytidine deaminases have been implicated as major contributors to the mutation burden in many cancers on the basis of their mutational signature. A new experimental study sheds light on the inciting factors, linking APOBEC3B expression to oncogene- and drug-induced replication stress.

PubMed Disclaimer

Comment on

  • DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
    Kanu N, Cerone MA, Goh G, Zalmas LP, Bartkova J, Dietzen M, McGranahan N, Rogers R, Law EK, Gromova I, Kschischo M, Walton MI, Rossanese OW, Bartek J, Harris RS, Venkatesan S, Swanton C. Kanu N, et al. Genome Biol. 2016 Sep 15;17(1):185. doi: 10.1186/s13059-016-1042-9. Genome Biol. 2016. PMID: 27634334 Free PMC article.

References

    1. Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SAJR, Behjati S, Biankin AV, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415–421. doi: 10.1038/nature12477. - DOI - PMC - PubMed
    1. Kanu N, Cerone MA, Goh G, Zalmas LP, Bartkova J, Dietzen M, et al. DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer. Gen Biol. 2016;17(1):185. doi: 10.1186/s13059-016-1042-9. - DOI - PMC - PubMed
    1. Burns MB, Lackey L, Carpenter MA, Rathore A, Land AM, Leonard B, et al. APOBEC3B is an enzymatic source of mutation in breast cancer. Nature. 2013;494:366–370. doi: 10.1038/nature11881. - DOI - PMC - PubMed
    1. Nik-Zainal S, Alexandrov LB, Wedge DC, Van Loo P, Greenman CD, Raine K, et al. Mutational processes molding the genomes of 21 breast cancers. Cell. 2012;149:979–993. doi: 10.1016/j.cell.2012.04.024. - DOI - PMC - PubMed
    1. Long J, Delahanty RJ, Li G, Gao Y-T, Lu W, Cai Q, et al. A common deletion in the APOBEC3 genes and breast cancer risk. J Natl Cancer Inst. 2013;105:573–579. doi: 10.1093/jnci/djt018. - DOI - PMC - PubMed

Publication types

Substances

Grants and funding