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Review
. 2016 Sep 30;9(1):528.
doi: 10.1186/s13071-016-1799-4.

Schistosomiasis vaccines: where do we stand?

Biniam Mathewos Tebeje  1   2   3 , Marina Harvie  4 , Hong You  4 , Alex Loukas  5 , Donald P McManus  6
Affiliations
Review

Schistosomiasis vaccines: where do we stand?

Biniam Mathewos Tebeje et al. Parasit Vectors. .

Abstract

Schistosomiasis, caused mainly by S. mansoni, S. haematobium and S. japonicum, continues to be a serious tropical disease and public health problem resulting in an unacceptably high level of morbidity in countries where it is endemic. Praziquantel, the only drug currently available for treatment, is unable to kill developing schistosomes, it does not prevent re-infection and its continued extensive use may result in the future emergence of drug-resistant parasites. This scenario provides impetus for the development and deployment of anti-schistosome vaccines to be used as part of an integrated approach for the prevention, control and eventual elimination of schistosomiasis. This review considers the present status of candidate vaccines for schistosomiasis, and provides some insight on future vaccine discovery and design.

Keywords: Antigen discovery; Immune protection; Immune response; Schistosoma haematobium; Schistosoma japonicum; Schistosoma mansoni; Schistosomiasis; Vaccine.

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References

    1. Sarvel AK, Oliveira AA, Silva AR, Lima AC, Katz N. Evaluation of a 25-year-program for the control of schistosomiasis mansoni in an endemic area in Brazil. PLoS Negl Trop Dis. 2011;5(3):e990. doi: 10.1371/journal.pntd.0000990. - DOI - PMC - PubMed
    1. World Health Organization. Schistosomiasis. In: Schistosomiasis Fact Sheet No 115. World Health Organization. 2015. http://www.who.int/mediacentre/factsheets/fs115/en/. Accessed Aug 2015.
    1. Nour NM. Schistosomiasis: health effects on women. Rev Obst Gynecol. 2010;3(1):28. - PMC - PubMed
    1. Christinet V, Lazdins-Helds JK, Stothard JR, Reinhard-Rupp J. Female genital schistosomiasis (FGS): from case reports to a call for concerted action against this neglected gynaecological disease. Int J Parasitol. 2016;46(7):395–404. doi: 10.1016/j.ijpara.2016.02.006. - DOI - PubMed
    1. Cioli D, Pica-Mattoccia L, Basso A, Guidi A. Schistosomiasis control: praziquantel forever? Mol Biochem Parasitol. 2014;195(1):23–9. doi: 10.1016/j.molbiopara.2014.06.002. - DOI - PubMed

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