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Comment
. 2016 Oct 6;167(2):310-312.
doi: 10.1016/j.cell.2016.09.043.

PIWI Takes a Giant Step

Yibei Xiao  1 , Ailong Ke  2
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PIWI Takes a Giant Step

Yibei Xiao et al. Cell. .
Free article

Abstract

piRNA guides the action of PIWI proteins to silence deleterious transposons in animal reproductive tissues. Biogenesis of piRNA-induced silencing complex (piRISC) involves a multi-step process. In this issue, Matsumoto et al. report the first crystal structure of a PIWI-clade protein displaying a guide RNA, ready for action.

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