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. 2016 Oct 7;12(1):223.
doi: 10.1186/s12917-016-0852-z.

Effect of intraarticular inoculation of mesenchymal stem cells in dogs with hip osteoarthritis by means of objective force platform gait analysis: concordance with numeric subjective scoring scales

Jose M Vilar  1 , Belen Cuervo  2 , Monica Rubio  2 , Joaquín Sopena  2 , Juan M Domínguez  3 , Angelo Santana  4 , Jose M Carrillo  2
Affiliations

Effect of intraarticular inoculation of mesenchymal stem cells in dogs with hip osteoarthritis by means of objective force platform gait analysis: concordance with numeric subjective scoring scales

Jose M Vilar et al. BMC Vet Res. .

Abstract

Background: Subjective pain assessment scales have been widely used for assessing lameness in response to pain, but the accuracy of these scales has been questioned. To assess scale accuracy, 10 lame, presa Canario dogs with osteoarthritis (OA) associated with bilateral hip dysplasia were first treated with mesenchymal stem cells. Then, potential lameness improvement was analyzed using two pain scales (Bioarth and visual analog scale). These data were compared with similar data collected using a force platform with the same animals during a period of 6 months after treatment.

Results: The F test for intraclass correlation showed that concordance in pain/lameness scores between the 2 measuring methodologies was not significant (P value ≥ 0.9213; 95 % confidence interval, -0.56, 0.11). Although subjective pain assessment showed improvement after 6 months, force platform data demonstrated those same animals had returned to the initial lameness state.

Conclusion: Use of pain assessment scales to measure lameness associated with OA did not have great accuracy and concordance when compared with quantitative force platform gait analysis.

Keywords: Dog; Force platform; Mesenchymal stem cells; Osteoarthritis; Pain assessment; Visual analog scale.

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Figures

Fig. 1
Fig. 1
Radiographs showing lesions corresponding with D-degree (a) and E-degree (b) hip dysplasia
Fig. 2
Fig. 2
Evolution of peak vertical force (PVF) in lame-group dogs after treatment with mesenchymal stem cells at days 30, 90, and 180. The control group is also shown for reference
Fig. 3
Fig. 3
Evolution of vertical impulse (VI) in lame-group dogs after treatment with mesenchymal stem cells at days 30, 90, and 180 follow-up. The control group is also shown for reference
Fig. 4
Fig. 4
Evolution of lameness in dogs using the Bioarth scoring scale at days 0, 30, 90, and 180 post-treatment with mesenchymal stem cells. The control group is also shown for comparison
Fig. 5
Fig. 5
Evolution of lameness in dogs using the visual analog scoring (VAS) scale at days 0, 30, 90, and 180 post-treatment with mesenchymal stem cells. The control group is also shown for comparison
See this image and copyright information in PMC

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