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Case Reports
. 2016 Dec;75(6):1274-1277.
doi: 10.1016/j.jaad.2016.09.015. Epub 2016 Oct 4.

Diffuse atrophic papules and plaques, intermittent abdominal pain, paresthesias, and cardiac abnormalities in a 55-year-old woman

Brittany Oliver  1 , Manfred Boehm  2 , Douglas R Rosing  3 , Lee S Shapiro  4 , Daniel T Dempsey  5 , Peter A Merkel  6 , Chyi-Chia Richard Lee  7 , Edward W Cowen  8
Affiliations
Case Reports

Diffuse atrophic papules and plaques, intermittent abdominal pain, paresthesias, and cardiac abnormalities in a 55-year-old woman

Brittany Oliver et al. J Am Acad Dermatol. 2016 Dec.

Abstract

KEY TEACHING POINTS.

Keywords: Degos disease; complement; eculizumab; interferon; malignant atrophic papulosis; treprostinil; vasculopathy.

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Conflict of interest statement

No other potential conflicts of interest relevant to this article were reported.

Figures

Figure 1
Figure 1
Malignant atrophic papulosis. (A) Porcelain white, irregularly shaped atrophic papules and plaques with erythematous, telangiectatic rim on the abdomen. (B) Close-up view of atrophic papules.
Figure 1
Figure 1
Malignant atrophic papulosis. (A) Porcelain white, irregularly shaped atrophic papules and plaques with erythematous, telangiectatic rim on the abdomen. (B) Close-up view of atrophic papules.
Figure 2
Figure 2
Dermatopathology of malignant atrophic papulosis. Lichenoid dermatitis with hyperkeratosis, patchy lymphocytic infiltrate, hemosiderin deposition, increased dermal mucin, and colloid bodies in the superficial dermis. (A) H&E, ×40; (B) H&E, ×400).
Figure 2
Figure 2
Dermatopathology of malignant atrophic papulosis. Lichenoid dermatitis with hyperkeratosis, patchy lymphocytic infiltrate, hemosiderin deposition, increased dermal mucin, and colloid bodies in the superficial dermis. (A) H&E, ×40; (B) H&E, ×400).
See this image and copyright information in PMC

References

    1. Katz SK, Mudd LJ, Roenigk HH. Malignant atrophic papulosis (Degos’ disease) involving three generations of a family. J Am Acad Dermatol. 1997;37:480–484. - PubMed
    1. Scheinfeld N. Malignant atrophic papulosis. Clin Exp Dermatol. 2007;32:483–487. - PubMed
    1. Heymann WR. Degos disease: Considerations for reclassification. J Am Acad Dermatol. 2009;61:505–506. - PubMed
    1. Magro CM, Poe JC, Kim C, Shapiro L, Nuovo G, Crow MK, et al. Degos disease: a C5b-9/Interferon-α-mediated endotheliopathy syndrome. Am J Clin Pathol. 2011;135(4):599–610. - PubMed
    1. Barlow RJ, Heyl T, Simson IW, Schulz EJ. Malignant atrophic papulosis (Degos’ disease) – diffuse involvement of brain and bowel in an African patient. Br J Dermatol. 1988;118:117–123. - PubMed

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