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Review
. 2017 Apr:64:48-57.
doi: 10.1016/j.semcdb.2016.10.001. Epub 2016 Oct 4.

Cancer heterogeneity and imaging

James P B O'Connor  1
Affiliations
Review

Cancer heterogeneity and imaging

James P B O'Connor. Semin Cell Dev Biol. 2017 Apr.

Abstract

There is interest in identifying and quantifying tumor heterogeneity at the genomic, tissue pathology and clinical imaging scales, as this may help better understand tumor biology and may yield useful biomarkers for guiding therapy-based decision making. This review focuses on the role and value of using x-ray, CT, MRI and PET based imaging methods that identify, measure and map tumor heterogeneity. In particular we highlight the potential value of these techniques and the key challenges required to validate and qualify these biomarkers for clinical use.

Keywords: Biomarker; Cancer; Heterogeneity; Imaging.

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