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Review
. 2017 Mar;20(Suppl 1):92-101.
doi: 10.1007/s10120-016-0655-8. Epub 2016 Oct 7.

Global chemotherapy development for gastric cancer

Kazuto Harada  1 , Dilsa Mizrak Kaya  1 , Yusuke Shimodaira  1 , Jaffer A Ajani  2
Affiliations
Review

Global chemotherapy development for gastric cancer

Kazuto Harada et al. Gastric Cancer. 2017 Mar.

Abstract

To combat the dismal mortality rates from metastatic gastric adenocarcinoma (GAC), new drugs and treatment strategies are needed. Today, metastatic GAC is predominantly treated by empiric chemotherapy. Combination of two cytotoxic agents has become commonplace in North America, Europe, and Asia. Human epidermal growth factor 2 (HER2) overexpression (protein or gene copy numbers) has resulted in the addition of trastuzumab in the first-line chemotherapy combination in patients whose tumor is HER2 positive. The addition of trastuzumab in this select population has provided a modest survival advantage. In this review we trace the global development of systemic therapy in patients with metastatic GAC and ponder what lies in the future.

Keywords: Chemotherapy; Gastric adenocarcinoma; Molecularly targeted drug.

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