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Review
. 2016 Dec:43:39-45.
doi: 10.1016/j.coi.2016.09.003. Epub 2016 Oct 5.

Targeting B cells in treatment of autoimmunity

S Elizabeth Franks  1 , Andrew Getahun  2 , P Mark Hogarth  3 , John C Cambier  4
Affiliations
Review

Targeting B cells in treatment of autoimmunity

S Elizabeth Franks et al. Curr Opin Immunol. 2016 Dec.

Abstract

B cells have emerged as effective targets for therapeutic intervention in autoimmunities in which the ultimate effectors are antibodies, as well as those in which T cells are primary drivers of inflammation. Proof of this principle has come primarily from studies of the efficacy of Rituximab, an anti-CD20 mAb that depletes B cells, in various autoimmune settings. These successes have inspired efforts to develop more effective anti-CD20s tailored for specific needs, as well as biologicals and small molecules that suppress B cell function without the risks inherent in B cell depletion. Here we review the current status of B cell-targeted therapies for autoimmunity.

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Figures

Figure 1
Figure 1
Proposed Mechanisms/Targets of B cell Therapies in Autoimmunity.
See this image and copyright information in PMC

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