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Review
. 2016 Aug;11(4):275-281.
doi: 10.1159/000447549. Epub 2016 Jul 28.

Systemic Therapy of Advanced/Metastatic Breast Cancer - Current Evidence and Future Concepts

Cornelia Liedtke  1 , Hans-Christian Kolberg  2
Affiliations
Review

Systemic Therapy of Advanced/Metastatic Breast Cancer - Current Evidence and Future Concepts

Cornelia Liedtke et al. Breast Care (Basel). 2016 Aug.

Abstract

Systemic therapy of metastatic breast cancer may include chemotherapy, endocrine therapy, and targeted therapies (e.g., antibody-based approaches). These agents may be employed alone or in combination based on the patient's breast cancer subtype. Therefore, characterization of the disease phenotype is necessary and may include biopsy of the metastatic site. Novel therapeutic approaches include immunologic therapies, PARP inhibitors, PI3K inhibitors, and CDK4/6 inhibitors, which are currently under investigation in clinical trials.

Keywords: Chemotherapy; Clinical trials; Endocrine therapy; Metastatic breast cancer; Molecular breast cancer subgroups; Targeted therapy.

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References

    1. References can be found online ( www.karger.com/?DOI=447549)