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Review
. 2016 Dec;14(4):410-419.
doi: 10.1007/s11938-016-0113-z.

Chronic Unexplained Nausea and Vomiting or Gastric Neuromuscular Dysfunction (GND)? An Update on Nomenclature, Pathophysiology and Treatment, and Relationship to Gastroparesis

Kimberly N Harer  1 , Pankaj J Pasricha  2
Affiliations
Review

Chronic Unexplained Nausea and Vomiting or Gastric Neuromuscular Dysfunction (GND)? An Update on Nomenclature, Pathophysiology and Treatment, and Relationship to Gastroparesis

Kimberly N Harer et al. Curr Treat Options Gastroenterol. 2016 Dec.

Abstract

Chronic unexplained nausea and vomiting is a debilitating condition that dramatically decreases patient quality of life and creates diagnostic and treatment challenges for healthcare providers. Additionally, the significant overlap in symptoms between disorders such as chronic unexplained nausea and vomiting, gastroparesis, and functional dyspepsia has resulted in a blurring of diagnostic lines and added confusion to the therapeutic approach. The identified overlap in clinical symptoms also suggests a common underlying pathophysiological mechanism may drive these conditions, indicating they could possibly be part of a spectrum of gastric neuromuscular disorders instead of discrete processes. This article will discuss the classification, updates in pathophysiology and therapeutic research, and future directions of research in the treatment of chronic unexplained nausea and vomiting.

Keywords: Chronic unexplained nausea and vomiting; Gastroparesis; Gastroparesis-like dysfunction; Nausea; Vomiting.

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Conflict of interest statement

Kimberly N. Harer declares no conflict of interest.

References

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