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Clinical Trial
. 1978 Jun:3:286-9.

Clinical studies with misonidazole

C R Wiltshire, P Workman, J V Watson, N M Bleehen
Clinical Trial

Clinical studies with misonidazole

C R Wiltshire et al. Br J Cancer Suppl. 1978 Jun.

Abstract

The preliminary details of a randomized clinical trial of misonidazole for the radiotherapy of Grades 3 and 4 cerebral astrocytoma are described. Plasma concentrations of misonidazole and its O-demethylated metabolite, determined by high-pressure liquid chromatography analysis, are reported for 8 patients with astrocytoma, 1 with carcinoma of the bronchus and 1 with carcinoma of the breast. In the latter case, tumour concentrations are also presented.

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References

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