Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2016 Oct 11:6:35214.
doi: 10.1038/srep35214.

Prognostic Value of Pre-operative Renal Insufficiency in Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Jian Cao  1   2 , Xiaokun Zhao  1 , Zhaohui Zhong  1 , Lei Zhang  1 , Xuan Zhu  1 , Ran Xu  1
Affiliations
Meta-Analysis

Prognostic Value of Pre-operative Renal Insufficiency in Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Jian Cao et al. Sci Rep. .

Abstract

The effect of pre-operative renal insufficiency on urothelial carcinoma (UC) prognosis has been investigated by numerous studies. While the majority report worse UC outcomes in patients with renal insufficiency, the results between the studies differed wildly. To enable us to better estimate the prognostic value of renal insufficiency on UC, we performed a systematic review and meta-analysis based on the published literature. A total of 16 studies which involved 5,232 patients with UC, investigated the relationship between pre-operative renal insufficiency and disease prognosis. Estimates of combined hazard ratio (HR) for bladder urothelial carcinoma recurrence, cancer-specific survival (CSS) and overall survival (OS) were 1.65 (95% CI, 1.11-2.19), 1.59 (95% CI, 1.14-2.05) and 1.45 (95% CI, 1.19-1.71), respectively; and for upper urinary tract urothelial carcinoma recurrence, CSS and OS were 2.27 (95% CI, 1.42-3.12), 1.02 (95% CI, 0.47-1.57) and 1.52 (95% CI, 1.05-1.99), respectively. Our results indicate that UC patients with pre-operative renal insufficiency tend to have higher recurrence rates and poorer survival compared to those with clinically normal renal function, thus renal function should be closely monitored in these patients. The impact of intervention for renal insufficiency on the prognosis of UC needs to be further studied.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Flow diagram of literature search and selection for meta-analysis.
Figure 2
Figure 2. Meta-analysis of the association between renal insufficient and prognosis of Bladder Urothelial Carcinoma.
(A) Recurrence for Bladder Cancer; (B) Cancer-specific Survival for Bladder Cancer; (C) Overall Survival for Bladder Cancer. Each study was shown by the name of the first author (publish year/patients numbers) and the HRs with 95% CIs.
Figure 3
Figure 3. Meta-analysis of the association between renal insufficient and Prognosis of Upper Urinary Tract Urothelial Carcinoma.
(A) Recurrence for Upper Urinary Tract Urothelial Carcinoma; (B) Cancer-specific Survival for Upper Urinary Tract Urothelial Carcinoma; (C) Overall Survival for Upper Urinary Tract Urothelial Carcinoma. Each study was shown by the name of the first author (publish year/patients numbers) and the HRs with 95% CIs.
See this image and copyright information in PMC

References

    1. Roupret M. et al.. European association of urology guidelines on upper urinary tract urothelial cell carcinoma: 2015 update. European Urology 68, 868–879 (2015). - PubMed
    1. Torre L. A. et al.. Global Cancer Statistics, 2012. CA a cancer J. Clin. 65, 87–108 (2015). - PubMed
    1. Rabbani F., Perrotti M., Russo P. & Herr H. W. Upper-tract tumors after an initial diagnosis of bladder cancer: argument for long-term surveillance. J. Clin. Oncol. 19, 94–100 (2001). - PubMed
    1. Matas A. J., Simmons R. L., Kjellstrand C. M., Buselmeier T. J. & Najarian J. S. Increased incidence of malignancy during chronic renal failure. Lancet 1, 883–886 (1975). - PubMed
    1. Cengiz K. Increased incidence of neoplasia in chronic renal failure (20-year experience). Int. Urol. Nephrol. 33, 121–126 (2002). - PubMed

Publication types

LinkOut - more resources