Gene Regulation: Activation through Space
- PMID: 27728794
- DOI: 10.1016/j.cub.2016.08.031
Gene Regulation: Activation through Space
Abstract
A recent study visualizes nascent RNAs in live Drosophila embryos to establish a connection between enhancer strength and the frequency of transcriptional bursts. Interestingly, one enhancer can simultaneously activate two core promoters, challenging models of enhancer-core-promoter communication via direct protein-protein contacts.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Comment on
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Enhancer Control of Transcriptional Bursting.Cell. 2016 Jul 14;166(2):358-368. doi: 10.1016/j.cell.2016.05.025. Epub 2016 Jun 9. Cell. 2016. PMID: 27293191 Free PMC article.
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A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting.Nat Commun. 2016 Jul 27;7:12248. doi: 10.1038/ncomms12248. Nat Commun. 2016. PMID: 27461529 Free PMC article.
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