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. 2016 Oct 10;30(4):505-507.
doi: 10.1016/j.ccell.2016.09.012.

SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse

Nicole R Murray  1 , Verline Justilien  1 , Alan P Fields  2
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SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse

Nicole R Murray et al. Cancer Cell. .
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Abstract

In this issue of Cancer Cell, Ferone et al. demonstrate that SOX2 not only drives lung tumor formation but also restricts tumor lineage to squamous cell carcinoma (LSCC), regardless of cell of origin. This novel LSCC model should facilitate identification of key oncogenic drivers and treatment strategies for this lung cancer subtype.

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