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. 2016 Oct 10;30(4):509-510.
doi: 10.1016/j.ccell.2016.09.013.

p62 in Liver Disease: Good Guy or Bad Guy?

Zexi Hu  1 , Lars Zender  2
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p62 in Liver Disease: Good Guy or Bad Guy?

Zexi Hu et al. Cancer Cell. .
Free article

Abstract

The multidomain adaptor protein p62 has been suggested to exert pro-oncogenic functions in hepatocytes and other epithelial cells. In this issue of Cancer Cell, Duran et al. show that p62 acts as a non-cell-autonomous tumor suppressor in liver cancer by counteracting the activation of hepatic stellate cells.

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