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Comment
. 2016 Oct 10;30(4):515-517.
doi: 10.1016/j.ccell.2016.09.016.

Targeting HIF2α in Clear-Cell Renal Cell Carcinoma

Christopher J Ricketts  1 , Daniel R Crooks  1 , W Marston Linehan  2
Affiliations
Free article
Comment

Targeting HIF2α in Clear-Cell Renal Cell Carcinoma

Christopher J Ricketts et al. Cancer Cell. .
Free article

Abstract

In two recent studies, the HIF2α antagonist, PT2399, decreased HIF2α-dependent transcription and tumor growth in selected VHL-deficient clear-cell renal cell carcinoma (ccRCC) models. These studies validate HIF2α as a therapeutic target in ccRCC, reveal variable sensitivity to HIF2α antagonism, and provide the foundation for predictive biomarker-driven clinical trials.

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