Cis-eQTLs regulate reduced LST1 gene and NCR3 gene expression and contribute to increased autoimmune disease risk

Guiyou Liu¹, Yang Hu¹, Shuilin Jin², Fang Zhang³, Qinghua Jiang⁴, Junwei Hao⁵

Affiliations

¹ School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.
² Department of Mathematics, Harbin Institute of Technology, Harbin 150001, China.
³ Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
⁴ School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China; hjw@tmu.edu.cn qhjiang@hit.edu.cn.
⁵ Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China hjw@tmu.edu.cn qhjiang@hit.edu.cn.

PMID: 27729515
PMCID: PMC5081638
DOI: 10.1073/pnas.1614369113

Comment

Cis-eQTLs regulate reduced LST1 gene and NCR3 gene expression and contribute to increased autoimmune disease risk

Guiyou Liu et al. Proc Natl Acad Sci U S A. 2016.

. 2016 Oct 18;113(42):E6321-E6322.

doi: 10.1073/pnas.1614369113. Epub 2016 Oct 11.

Authors

Guiyou Liu¹, Yang Hu¹, Shuilin Jin², Fang Zhang³, Qinghua Jiang⁴, Junwei Hao⁵

Affiliations

¹ School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.
² Department of Mathematics, Harbin Institute of Technology, Harbin 150001, China.
³ Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
⁴ School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China; hjw@tmu.edu.cn qhjiang@hit.edu.cn.
⁵ Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China hjw@tmu.edu.cn qhjiang@hit.edu.cn.

PMID: 27729515
PMCID: PMC5081638
DOI: 10.1073/pnas.1614369113

No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Comment in

Reply to Liu et al.: Translation of rat congenic data to humans on a conserved MHC-III haplotype associated with rheumatoid arthritis.
Yau AC, Houtman M, Padyukov L, Holmdahl R. Yau AC, et al. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6323-E6324. doi: 10.1073/pnas.1614662113. Epub 2016 Oct 11. Proc Natl Acad Sci U S A. 2016. PMID: 27729538 Free PMC article. No abstract available.

Comment on

Conserved 33-kb haplotype in the MHC class III region regulates chronic arthritis.
Yau AC, Tuncel J, Haag S, Norin U, Houtman M, Padyukov L, Holmdahl R. Yau AC, et al. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3716-24. doi: 10.1073/pnas.1600567113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303036 Free PMC article.

References

1. Yau ACY, et al. Conserved 33-kb haplotype in the MHC class III region regulates chronic arthritis. Proc Natl Acad Sci USA. 2016;113(26):E3716–E3724. - PMC - PubMed
1. Zou F, et al. Alzheimer’s Disease Genetics Consortium Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet. 2012;8(6):e1002707. - PMC - PubMed
1. Liu G, Bao X, Wang R. Expression quantitative trait loci regulate HNF4A and PTBP1 expression in human brains. Proc Natl Acad Sci USA. 2015;112(30):E3975. - PMC - PubMed
1. Walsh AM, et al. Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associations. Genome Biol. 2016;17:79. - PMC - PubMed
1. Okada Y, et al. RACI consortium GARNET consortium Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature. 2014;506(7488):376–381. - PMC - PubMed

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Cis-eQTLs regulate reduced LST1 gene and NCR3 gene expression and contribute to increased autoimmune disease risk

Affiliations

Cis-eQTLs regulate reduced LST1 gene and NCR3 gene expression and contribute to increased autoimmune disease risk

Authors

Affiliations

Conflict of interest statement

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References

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