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. 2015 Dec 28;7(4):231-237.

Tadalafil for Endometrial Growth in Clomiphene Citrate stimulated cycles in an IUI programma: A pilot study

D H Mendez Lozano  1 , M V Lenero  2 , R L Gonzalez  1 , J B Scheffer  3 , M T Gonzalez  2 , Y Barron  2 , R Frydman  4
Affiliations

Tadalafil for Endometrial Growth in Clomiphene Citrate stimulated cycles in an IUI programma: A pilot study

D H Mendez Lozano et al. Facts Views Vis Obgyn. .

Abstract

Aim of the study: The objective of this study was to assess the impact of tadalafil on endometrial growth, the uterine artery pulsatility index (PI) and the uterine artery resistance index (RI) in patients under clomiphene ovarian stimulation for intrauterine insemination (IUI).

Methods: This randomized crossover study included 30 patients with a normal endometrium over 53 cycles, and 46 of those cycles in 23 patients were included in the analysis. In group A the patients were under 100 mg clomiphene daily for five days (2-6) and 5 mg tadalafil daily for 7 days (4-10). For Group B (control) the patients only received clomiphene. Measurements of the endometrium, PI, RI and estradiol determinations were taken on cycle days 4, 8 and 10.

Results: We observed a better endometrial growth in Group A compared to Group B: 7.5 ± 2.1 mm vs 5.5 ± 1.2 mm, P < 0.0002 and 8.9 ± 1.8 mm vs 6.3 ± 1.8 mm, P < 0.0002 on days 8 and 10, respectively. Additionally, a progressive decrease in the RI was observed in Group A but not in Group B from day 8 (0.77 ± 0.15 vs 0.85 ± 0.18, P = 0.059) to day 10 (0.74 ± 0.20 vs 0.87 ± 0.14, P < 0.017). However, no differences were observed in PI or serum estradiol between Group A and Group B.

Conclusion: The use of tadalafil improved endometrial growth in patients under clomiphene ovarian stimulation with no significant effect on the uterine artery Pulsatility Index and serum estradiol.

Keywords: Clomiphene citrate; Endometrial growth; Pulsatility Index; Resistance Index; Tadalafil; ovarian stimulation.

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Figures

Figure 1
Figure 1
— Cross-over randomized study: flow-diagram of the study
Figure 2
Figure 2
— Comparison of endometrial growth on Day 4, 8 and 10 between Group A (cycle A) and Group B (cycle B).
Figure 3
Figure 3
— Comparison of resistance index (RI) on Day 4, 8 and 10 between Group A (cycle A) and Group B (cycle B).
See this image and copyright information in PMC

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