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Comment
. 2016 Oct 11;24(4):526-528.
doi: 10.1016/j.cmet.2016.09.019.

Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis

Leonard Guarente  1
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Free article
Comment

Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis

Leonard Guarente. Cell Metab. .
Free article

Abstract

In this issue, Fang et al. (2016) show that both the DNA repair defect and mitochondrial dysfunction in ATM-/- cells or mice are mitigated by the anti-aging compound nicotinamide riboside or a SIRT1 activator. This broad suppression by activating the NAD+/SIRT1 axis may generally apply to diseases and aging maladies.

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