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Comment
. 2016 Oct 11;24(4):529-530.
doi: 10.1016/j.cmet.2016.09.020.

Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate

Maxime Janin  1 , Manel Esteller  2
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Free article
Comment

Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate

Maxime Janin et al. Cell Metab. .
Free article

Abstract

Mutations to the Krebs cycle enzyme fumarate hydratase in cancer cells leads to an accumulation of the oncometabolite fumarate. Sciacovelli et al. (2016) demonstrate an epigenetically dependent epithelial-to-mesenchymal transition mediated by modulation of the miR-200 cluster and TET demethylation in response to fumarate accumulation.

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  • Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.
    Sciacovelli M, Gonçalves E, Johnson TI, Zecchini VR, da Costa AS, Gaude E, Drubbel AV, Theobald SJ, Abbo SR, Tran MG, Rajeeve V, Cardaci S, Foster S, Yun H, Cutillas P, Warren A, Gnanapragasam V, Gottlieb E, Franze K, Huntly B, Maher ER, Maxwell PH, Saez-Rodriguez J, Frezza C. Sciacovelli M, et al. Nature. 2016 Aug 31;537(7621):544-547. doi: 10.1038/nature19353. Nature. 2016. PMID: 27580029 Free PMC article.

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