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Comment
. 2016 Oct 11;17(3):625-626.
doi: 10.1016/j.celrep.2016.09.085.

A Metabolic Roadblock in Inflammatory Macrophages

Luke A J O'Neill  1
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A Metabolic Roadblock in Inflammatory Macrophages

Luke A J O'Neill. Cell Rep. .
Free article

Abstract

In this issue of Cell Reports, Van den Bossche et al. (2016) reveal that, once the M1 macrophage forms, the accompanying metabolic alterations in the mitochondria are irreversible, preventing differentiation into the more homeostatic M2 macrophage.

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