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. 2016 Oct 13;11(10):e0164341.
doi: 10.1371/journal.pone.0164341. eCollection 2016.

Musculoskeletal Complaints (Pain and/or Stiffness) and Their Impact on Mortality in the General Population. The Tromsø Study

Ole Fredrik Andorsen  1 , Luai Awad Ahmed  2   3 , Nina Emaus  2 , Elise Klouman  1
Affiliations

Musculoskeletal Complaints (Pain and/or Stiffness) and Their Impact on Mortality in the General Population. The Tromsø Study

Ole Fredrik Andorsen et al. PLoS One. .

Abstract

Background: The long-term consequences of chronic pain and/or stiffness from the musculoskeletal system (musculoskeletal complaints: MSCs) have not been well explored. The aims of this study were to investigate whether MSCs reported at baseline influence all-cause and cause-specific mortality during 21 years follow-up of a general Northern Norwegian adult population.

Methods: A total of 26,977 men and women aged 25-97 years who participated in the 1994-1995 survey of the Tromsø study (response rate 77%) were included in the present prospective cohort study. Baseline data were collected from the 1994-1995 survey and information on death and emigration was taken from the National Register of Norway. Cox regression analyses were performed to examine if MSCs predicted risk of mortality.

Results: 5693 (21.1%) participants died during follow-up. Mean time between entry into the survey and death or emigration was 18.6 years (standard deviation 4.87) for all-cause mortality. There was an increased risk of death among those with MSCs at baseline in the crude Cox regression model. However, the multivariable model revealed no significant association between MSCs at baseline and all-cause mortality by sex (women: hazard ratio [HR] = 0.93, 95% confidence interval [CI]: 0.85-1.01; men: HR = 0.93, 95%CI: 0.85-1.01). Furthermore, no significant associations were found between widespread MSCs at baseline and all-cause mortality in multivariable models (women: HR = 0.90, 95%CI: 0.80-1.01; men HR = 0.87, 95%CI: 0.76-1.00). Analyses on cause-specific mortality did not reveal any significant results.

Conclusion: MSCs are not independently associated with increased risk of death from cardiovascular disease, cancer, or death from all causes.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Hazard ratios (HRs) and 95% confidence intervals (CIs) stratified by sex and 10-year age groups from a univariable Cox regression model of all-cause mortality among participants with musculoskeletal complaints (MSCs) or widespread MSCs in a prospective cohort study of an adult general population in Northern Norway.
The Tromsø study.
See this image and copyright information in PMC

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