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. 2017 Feb 14;8(7):12355-12363.
doi: 10.18632/oncotarget.12563.

Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer

Chengquan Ma  1 , Yaguang Zhou  2 , Sufen Zhou  3 , Kun Zhao  4 , Bingxin Lu  5 , Erlin Sun  4
Affiliations

Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer

Chengquan Ma et al. Oncotarget. .

Abstract

Background and aim: High levels of peripheral plasma fibrinogen have recently been revealed that related to poor clinical prognosis in various types of malignant tumors. The purpose of this research was to identify the prognostic significance of the preoperative peripheral serum fibrinogen level in patients with penile cell carcinoma.

Methods: This retrospective research included 72 penile cancer patients with date about their serum fibrinogen value before surgery who undergone either partial or radical penectomy at The 2nd Hospital of Tianjin Medical University between January 2002 to January 2012. They had a mean follow-up of 30.8 months. To determine the factors that were significant in predicting a patient's prognosis, univariate and multivariate analyses were performed according to the Cox proportional hazards regression model.

Results: The 5-year cancer specific survival (CSS) rate was 62.4% of patients with preoperative fibrinogen levels below 340 mg/dl and 41.9% for those with higher levels (p = 0.001). Multivariate analysis revealed that the pathological T stage (p < 0.001), tumor grade (p = 0.036), postoperative chemotherapy (p = 0.041), nodal metastasis(p < 0.001), pathological type (p < 0.001) and fibrinogen (p = 0.023) were independent prognostic factors for survival. Patients with low fibrinogen level (<340mg/dl) had significantly longer CSS and the different survival rate were defined using the log-rank test.

Conclusions: The high preoperative peripheral serum fibrinogen level was related to poor survival in penile cancer patients. Fibrinogen may serve as a powerful predictor of CSS in penile cancer patients.

Keywords: biomarker; fibrinogen; penile cancer; prognosis; survival.

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Conflict of interest statement

CONFLICTS OF INTERESTS

All the authors declare they have no competing of interest.

Figures

Figure 1
Figure 1. Receiver operating curve (ROC) for predicting patients’ prognosis with fibrinogen
Figure 2
Figure 2. Cancer-specific survival (CSS) by plasma fibrinogen level between the ≥ 340 mg/dl and < 340 mg/dl fibrinogen groups
Figure 3
Figure 3. Cancer-specific survival (CSS) by tumor stage between the ≥ T2 and < T2 groups
Figure 4
Figure 4. Cancer-specific survival (CSS) by tumor grade between the G1-2 and G3-4 groups
Figure 5
Figure 5. Cancer-specific survival (CSS) by nodal metastasis between the N0 and N+ groups
Figure 6
Figure 6. Cancer-specific survival (CSS) by postoperative chemotherapy between yes and no groups
Figure 7
Figure 7. Cancer-specific survival (CSS) by pathological type between squamous carcinoma and other carcinoma groups
See this image and copyright information in PMC

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