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. 2016:2016:6140854.
doi: 10.1155/2016/6140854. Epub 2016 Sep 22.

Blue Laser Imaging-Bright Improves Endoscopic Recognition of Superficial Esophageal Squamous Cell Carcinoma

Akira Tomie  1 , Osamu Dohi  2 , Nobuaki Yagi  1 , Hiroaki Kitae  1 , Atsushi Majima  2 , Yusuke Horii  2 , Tomoko Kitaichi  2 , Yuriko Onozawa  2 , Kentaro Suzuki  2 , Reiko Kimura-Tsuchiya  3 , Tetsuya Okayama  2 , Naohisa Yoshida  2 , Kazuhiro Kamada  2 , Kazuhiro Katada  2 , Kazuhiko Uchiyama  2 , Takeshi Ishikawa  2 , Tomohisa Takagi  2 , Osamu Handa  2 , Hideyuki Konishi  2 , Yuji Naito  2 , Yoshito Itoh  2
Affiliations

Blue Laser Imaging-Bright Improves Endoscopic Recognition of Superficial Esophageal Squamous Cell Carcinoma

Akira Tomie et al. Gastroenterol Res Pract. 2016.

Abstract

Background/Aims. The aim of this study was to evaluate the endoscopic recognition of esophageal squamous cell carcinoma (ESCC) using four different methods (Olympus white light imaging (O-WLI), Fujifilm white light imaging (F-WLI), narrow band imaging (NBI), and blue laser imaging- (BLI-) bright). Methods. We retrospectively analyzed 25 superficial ESCCs that had been examined using the four different methods. Subjective evaluation was provided by three endoscopists as a ranking score (RS) of each image based on the ease of detection of the cancerous area. For the objective evaluation we calculated the color difference scores (CDS) between the cancerous and noncancerous areas with each of the four methods. Results. There was no difference between the mean RS of O-WLI and F-WLI. The mean RS of NBI was significantly higher than that of O-WLI and that of BLI-bright was significantly higher than that of F-WLI. Moreover, the mean RS of BLI-bright was significantly higher than that of NBI. Furthermore, in the objective evaluation, the mean CDS of BLI-bright was significantly higher than that of O-WLI, F-WLI, and NBI. Conclusion. The recognition of superficial ESCC using BLI-bright was more efficacious than the other methods tested both subjectively and objectively.

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Conflict of interest statement

Yoshito Itoh has an affiliation with a domination-funded department from Fujifilm Medical Co., Ltd. The other authors have no financial conflict of interests.

Figures

Figure 1
Figure 1
Representative still images: superficial flat depressed lesion(0-IIc type) on the middle thoracic esophagus. (a) O-WLI image, (b) F-WLI image, (c) NBI image, and (d) BLI-bright image.
Figure 2
Figure 2
Representative still images illustrating the spots captured for the color difference score (CDS) calculation of the lesion and background mucosa (Figure 1). (a) O-WLI image, (b) F-WLI image, (c) NBI image, and (d) BLI-bright image. The lesion was captured for image processing, and the region of interest (ROI) was highlighted to calculate the CDS using each of the four methods.
Figure 3
Figure 3
In the L ∗ a ∗ b ∗ color space system the color differences are visualized as distances in a diagram. L ∗: color brightness (L ∗ = 0 is black and L ∗ = 100 is white). a ∗: position between red and green (negative values are progreen; positive values are prored). b ∗: position between yellow and blue (negative values are problue; positive values are proyellow).
Figure 4
Figure 4
Subjective evaluation. Statistical comparison of the ranking score of O-WLI, F-WLI, NBI, and BLI-bright images for quality of ESCC visualization (Wilcoxon signed-rank test). Numbers above each row denote the numbers of ESCCs. ∗ P < 0.01.
Figure 5
Figure 5
Objective evaluation. Statistical comparison of the mean CDS of O-WLI, F-WLI, NBI, and BLI-bright images for quality of ESCC visualization (Wilcoxon signed-rank test). n.s.: not significant. ∗ P < 0.01, ∗∗ P < 0.05.
See this image and copyright information in PMC

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